6-羟基多巴胺*，6-羟基多巴胺技术资料

6-羟基多巴胺*，6-羟基多巴胺技术资料，南京九游AG信誉代理销售6-羟基多巴胺，欢迎大家！

6-羟基多巴胺

6-Hydroxydopamine hydrobromide

Appearance:light grey to khaki

Purity：98%

Chemical Structure:

Oxidopamine hydrobromide is a selective catecholaminergic neurotoxin, depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons.

6-羟基多巴胺*，6-羟基多巴胺技术资料

In vitro: Oxidopamine hydrobromide-induced apoptosis of PC12 cells was initiated by superoxide generation followed by caspase cascade activation, which was associated with the suppressed Akt phosphorylation and increased p38 phosphorylation. It is likely that pCPT-cAMP prevented the Oxidopamine hydrobromide-induced apoptosis via activation of the PI3-kinase/Akt pathway without any effect on superoxide generation or mitochondrial membrane depolarization. In vivo the presence of sulfhydryl antioxidants protected against neuronal degeneration in the striatum, which was particularly remarkable in the case of CySH and was attributed to its capacity to remove the H2O2 produced in the autoxidation of Oxidopamine hydrobromide.

6-羟基多巴胺*，6-羟基多巴胺技术资料